Abstract
AbstractThe impact of polyanions – sodium polystyrene sulfonate and sodium polyacrylate – on the rate of decapsulation of liposomal pH‐sensitive nanocontainers is investigated. The release properties are studied by means of laser microelectrophoresis and conductometery. Incorporation of capable to change its conformation after protonation trans‐4,5‐didodecyloxycarbonyl‐2‐morpholinocyclohexanol in electroneutral liposomes results in formation of pH‐sensitive nanocontainers (fliposomes) that release payload in slight acidic media. Pairing of this fliposomes with polyanions results in increase of rate of release of encapsulated water‐soluble compounds. Strong polyacid is found to induce release even at neutral pH. By means of fluorescence microscopy it is found that bare fliposomes being adsorbed on model cell membranes in acidic media while modified with polyanions nanocontainers provided release in intercellular environment.
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