Abstract
Apparent stability constants in water of approximately 100 molecular complexes formed between aromatic acids hydroxylated to varying degrees and their salts, on one hand, and four organic compounds, theophylline, hydrocortisone, prednisolone, and phenacetin, on the other, are reported. The data show that introduction of —OH into the first group, particularly ortho to a carboxylate grouping, produced marked enhancement in binding. The relative magnitude of the constants suggest that neither the squeezing out force nor hydrogen bonding is significantly responsible in most instances for the observed effects.
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