Complexation of Organic Substances in Aqueous Solution by Hydroxyaromatic Acids and Their Salts II.: Influence of Halogen, Nitro, and Other Substituents and Correlation of Binding Tendencies Toward Prednisolone, Theophylline, and Phenacetin

Abstract

Complexing tendencies of (<i>a</i>) variously substituted halo, methyl, nitro, and amino benzoates, (<i>b</i>) several phthalates, (<i>c</i>) dihydroxyphthalates, (<i>d</i>) dihydroxy and halohydroxy-2-naphthoates, and (<i>e</i>) pamoate have been evaluated by the solubility technique. The rather generalized binding effects observed earlier were again observed. Of all the salts studied, sodium pamoate exhibited the strongest tendency with a stability constant of 160 L./mole for prednisolone.