Abstract
Germ cell tumors (GCTs) are a common malignancy in males, with variations in differentiation making different therapeutic strategies necessary. Generally, GCTs show good curation rates due to their good response to radiotherapy or chemotherapy. However, certain subtypes are resistant to these therapies and require surgery. We present a case of a 25-year-old patient with a large retroperitoneal GCT with somatic malignant transformation, where resection of large abdominal blood vessels with complex reconstruction was necessary to completely remove the tumor. The tumor was completely resected, and the patient has since been recurrence-free in the follow-up period. GCTs with somatic transformation show high resistance rates to chemo- and radiotherapy, and the patient in the presented case study did indeed show only a limited response to carboplatin-based chemotherapy. Patients suffering from these conditions should be resected whenever possible, as curation can be achieved by complete tumor resection. Infiltration of neighboring structures is no contraindication to surgery. The case presented here shows that interdisciplinary surgical planning including vascular and general surgeons as well as radiologists is vital to ensure successful tumor resection.
Highlights
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Germ cell tumors (GCTs) show good therapeutic response even when discovered in patients with existing metastases, and cure rates of up to 80% can be achieved [6]
Macroscopic histopathological analyses showed a tumor 10.2 cm in diameter resected en bloc with the infrarenal aorta, the left ureter and Gerota fat, internal iliac artery and vein as well as the psoas muscle
Summary
Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. GCTs show good therapeutic response even when discovered in patients with existing metastases, and cure rates of up to 80% can be achieved [6]. Of these histological subtypes, somatic malignant transformation (SMT) is extremely rare, making up 2% of all male GCTs [7]. Showed only minimal response therapy and revealed vealed addition thrombosis of the left common and internal iliactovein. It became apparin of the left common and internal iliac vein.
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