Complex compound of heparin and glutamic acid: synthesis and effect on hemostasis parameters in vitro and in vivo

Abstract

A complex compound of high-molecular heparin and glutamic acid has been synthesized. This compound has anticoagulant, fibrinolytic, and antithrombotic properties in vitro. Single intravenous or chronic peroral introduction of the complex in normal animals imitates the activation of anticoagulation system. When the anticoagulation system in depressed, the complex restores or even activates the anticoagulant-fibrinolytic background of the serum it. The obtained data are discussed in physiological terms.