Abstract
Completing the Candida Loop
Highlights
Imagine identical twin sisters, one short, dark-haired, and zaftig; the other tall, blond, and willowy
A common human pathogen, C. albicans, most commonly exists in what is known as the white form—rounded yeast cells that grow as hemispheric white colonies
Rebecca Zordan, Mathew Miller, and colleagues fleshed out the circuitry responsible for the C. albicans whiteopaque switch, identifying two genes that, along with enhanced filamentous growth 1 (EFG1) and white-opaque regulator 1 (WOR1), make up a network of positive-feedback loops
Summary
One short, dark-haired, and zaftig; the other tall, blond, and willowy. Like the fungus Candida albicans, can assume dramatically different, heritable forms even though they share identical genes.
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