Abstract
We report the complete genome sequences of five human coronavirus NL63 (HCoV-NL63) strains obtained using next-generation sequencing. The five HCoV-NL63 strains were obtained from hospitalized children with severe acute respiratory infection detected in Guangdong, China. This study provides several complete genomes of HCoV-NL63 and improves our understanding of HCoV-NL63 evolution in China.
Highlights
Human coronavirus NL63 (HCoV-NL63) is a member of the family Coronaviridae, genus Alphacoronavirus, and was first discovered in 2004 (1)
1,686 1,686 1,623 1,623 1,600 1,600 1,690 1,690 754 754 1,710 1,710 1,682 1,682 1,808 1,808 1,596 1,596 1,659 1,659 1,435 1,435 1,378 1,378 2,103 2,103 2,394 2,394 2,043 2,043 1,864 1,864 1,118 1,118 1,056 1,056 Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown designed and used to amplify the gap region of HCoV-NL63, which was used for genome assemblies using the SeqMan subprogram of the DNAStar software version 7.1.0 with default parameters (Table 1)
Two complete genome sequences of HCoV-NL63 associated with acute respiratory illness have been obtained and reported in China
Summary
Human coronavirus NL63 (HCoV-NL63) is a member of the family Coronaviridae, genus Alphacoronavirus, and was first discovered in 2004 (1). 1F 1R 2F 2R 3F 3R 4F 4R 5F 5R 6F 6R 7F 7R 8F 8R 9F 9R 10F 10R 11F 11R 12F 12R 13F 13R 14F 14R 15F 15R 16F 16R 17F 17R 18F 18R GSP 1 AP GSP 2 AUAP AAP GSP 1 AUAP GSP 2 GSP3
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