Abstract
The response to possible precursors of methionine was determined in 137 methionine-requiring mutants ofSchizosaccharomyces pombe. Probably, homocysteine is directly synthesized from homoserine and sulphate. One mutant, growing on synthetic medium with vitamin B12 only, indicates a side pathway. Six complementation groups were observed in a sample of 27 homocysteine-requiring mutants.Met-3 andmet-4 were found to be allelic with a distance smaller than 0.01 recombination unit, which demonstrates that the second linkage group inS. pombe, proposed earlier, is a continuation of the linkage group presented byLeupold (1958).
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