Complementary effect of combination of statins with coenzyme q10 and omega-3 fatty acids in patients with combined dyslipidemia

Abstract

s / Atherosclerosis 241 (2015) e149ee229 e207 EAS-0936. COMPLEMENTARY EFFECT OF COMBINATION OF STATINS WITH COENZYME Q10 AND OMEGA-3 FATTY ACIDS IN PATIENTS WITH COMBINED DYSLIPIDEMIA S. T oth, M. Sajty, T. Pek arov a, J. Feda cko, K. Spi s akov a, D. Pella. 1st Department of Internal Medicine, avol Jozef Saf arik University in Ko sice Faculty of Medicine, Kosice, Slovakia * Corresponding author. Introduction: Several studies have described a positive effect of statins and omega-3 PUFA or CoQ10 on cardiovascular system. The aim of this study was to determine the effect of this triple combination on various parameters associated with the progression of cardiovascular disorders. Material and methods: 90 patients taking statins at a dose, which allowed target LDL levels, but with remained elevated TG levels (1.5-4.5 mmol/L) were randomized into three groups (each N1⁄430). In the placebocontrol group we indicated continued administration of statins. In the groups with additive treatment patients continued use of statins in combination with omega-3 PUFA 3 g/day respectively omega-3 PUFA 3 g/ day and 200 mg CoQ10/day during three months. After 3 months (± 1 week), we performed a final examination and collection of samples. We observed the lipid profile (total cholesterol, HDL, LDL, TG), hsCRP levels, activity SOD and GPx and presence of negative pleiotropic effects of statins. Results: Combination of statins with omega-3 PUFA significantly reduced TG and increased HDL levels. Significant reduction of hsCRP and increse of GTx and SOD was detected as well. Triple combination significantly decreased LDL and increased HDL in compare to control and dual combination. hsCRP significantly decreased in compare to control and dual combination group. SOD significantly increased in compare to control and dual combination group and GPx in compare to control. Conclusion: According to our study we suggest positive and complementary effect of combined therapy on lipid parameters, endothelial function and some negative pleiotropic effects of statins. EAS-0948. STATINS IMPACT IN A PORTUGUESE PRIMARY CARE UNIT J. Frutuoso. Internal Medicine, Hospital Jos e Joaquim Fernandes, Beja,