Abstract
Complement fixing antibrain antibodies were found in cerebrospinal fluid (CSF) from 6 of 12 patients with multiple sclerosis (MS), but not in any of 17 CSF specimens from patients with other neurological disorders when tested with a crude MS brain preparation as antigen. Complement fixing antibrain antibodies in lower titres were also found in 5 of the 6 positive MS CSF specimens when tested with a control brain preparation as antigen. The findings indicate the occurrence in MS of an immunization against brain components.
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