Abstract
BackgroundCoronary artery disease (CAD) is the leading cause of mortality and morbidity worldwide. Previous studies have shown that complement component 3 (C3) is associated with atherosclerosis and cardiovascular risk factors.MethodsWe conducted this study to evaluate the associations between tagSNPs in the C3 gene locus and the CAD susceptibility and lipid levels in the Chinese population. A hospital-based case-control study, including 1017 subjects (580 CAD patients and 437 non-CAD controls), was conducted. TagSNPs in the C3 gene were searched and genotyped by using the polymerase chain reaction-ligase detection reaction method.ResultsThe C3 levels were positively associated with the low-density lipoprotein cholesterol (LDL-C) levels (r = 0.269, P = 0.001). Compared with those in controls, the serum C3 levels in CAD patients were significantly higher (Control: 0.94 + 0.14 g/l; CAD: 1.10 + 0.19 g/l, P < 0.001). No significant differences in genotype or allele frequencies were observed between CAD patients and controls. The minor T allele of rs2287848 was associated with low apolipoprotein A1 (ApoA1) levels in controls (Bonferroni corrected P, Pc = 0.032). Linkage disequilibrium and haplotype analysis established two haplotype blocks (Block1: rs344555-rs2277984, Block 2: rs2287848-rs11672613) and six haplotypes. No significant associations between haplotypes and the risk of CAD were observed (all Pc > 0.05).ConclusionsThe results revealed that C3 gene polymorphisms were associated with the lipid levels, but not CAD susceptibility in the Chinese population.
Highlights
Coronary artery disease (CAD) is the leading cause of mortality and morbidity in developed countries, as well as in developing countries [1]
The prevalence of males and rates of essential hypertension (EH), diabetes mellitus (DM) and smoking were higher among patients than among controls
We found that the component 3 (C3) level was positively associated with the low-density lipoprotein cholesterol (LDL-C) levels and risk of CAD, which was consistent with previous results
Summary
Coronary artery disease (CAD) is the leading cause of mortality and morbidity in developed countries, as well as in developing countries [1]. China is representative of a developing country. With the increasing trend of aging in China, the incidence of CAD is bound to increase. Studies have found that activation of complement system plays an important role in the pathogenesis of CAD [4]. Activation of C3 is the most important step for the biological activity of the complement system. Coronary artery disease (CAD) is the leading cause of mortality and morbidity worldwide. Previous studies have shown that complement component 3 (C3) is associated with atherosclerosis and cardiovascular risk factors
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