Abstract

In the present paper we report an accurate method to quantify the accumulation of radiolabelled dopamine in striatal synaptosomes after superfusion of these particles with low concentrations of 3H-dopamine. Compartmental analysis of the efflux of radioactivity following 3H-dopamine accumulation was carried out. Moreover, the effects of some drugs and the uptake kinetics were studied in order to confirm that 3H-dopamine was accumulated in dopaminergic synaptosomes. The data show that:

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