Abstract
We measure transmitted signals with time, aperture, and angle gating for comparison in micro-sphere suspension, chicken breast and chicken liver tissues. We find that in each sample, the small aperture-gated (angle-gated) signals for imaging are essentially different from those of early time gating. Meanwhile, the signals obtained from aperture and angle gating come from quite different parts of the transmitted photons. For biological tissues of different structures, different gating methods may lead to different levels of imaging quality. Also, the results indicate the generally different scattering characteristics of biological tissues from that of a particle-based phantom. The scattering nature in the biological tissues may imply that random continuum scattering needs to be considered in biological imaging. Between chicken breast and liver tissues, the time-gated data show that the later has stronger scattering and absorption.
Highlights
The understanding of optical scattering properties is a key to the developments of efficient biological imaging techniques
From the data in the combinations of time/aperture and time/angle gating, we discovered that the small aperturegated signals for imaging were essentially different from those of early timegating
All the three gating methods might lead to effective biological imaging, they basically collected different portions of transmitted signals for imaging
Summary
The understanding of optical scattering properties is a key to the developments of efficient biological imaging techniques. To explore the scattering properties in biological tissues, Monte Carlo algorithms have been widely employed for simulating photon migration in a tissue sample In such an algorithm, the concept of discrete scattering of random nature is utilized. The effective scattering and absorption coefficients of a phantom or in a Monte Carlo simulation can describe certain photon migration characteristics, there may exist other optical scattering properties, which cannot be well described by these two parameters. Such optical scattering properties can be quite important for optical imaging applications.
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