Comparison the Presence of Serum Level of Albumin, Uric Acid and Creatinine in Pregnant Women Developed Symptoms of Preeclampsia and Who are Free from Symptoms of Preeclampsia: A Prospective Study

Abstract

Background: Preeclampsia, a hypertension condition that develops during pregnancy, is one of the most common causes of premature labour and delivery, perinatal death, and maternal mortality. Preeclampsia and other hypertensive diseases of pregnancy complicate a significant percentage of all pregnancies, necessitating early detection and warning. Objective: The aim of this study is to compare the presence of serum level of albumin, uric acid and creatinine in pregnant women who developed symptoms of preeclampsia and who are free from symptoms of preeclampsia. Method: A prospective study was carried out among 119 pregnant women in the outpatient Department of obstetrics and Gynaecology, Bangabandhu Sheikh Mujib Medical University, Bangladesh, from June 2005 July 2006.Details and data obtained from medical records section were analyzed. Results: Among 119 women, PE developed in 10 patients and 109 patients remain normotensive. Among the study group incidence of PE was 8.4%. The mean age was 25.48±5.26 vs 25.60±3.89 in control vs PE subjects respectively. At booking the mean SBP was 104.40±10.67 vs 121.50±6.26, mean DBP was 65.73±6.41 vs 68.00±5.87, mean MAP was 77.66±5.28 vs 78.62±6.39 respectively in control and PE subjects. The mean serum albumin (gm/dl) of the study groups were as follows: control 2.97±0.55 vs PE 3.73±0.52. Serum creatinine of the study group (0.78±8.5 and 0.79±6.11 in control vs PE) and serum uric acid (2.24±0.71 and 2.65±0.56 in control vs PE) shows no significant difference at booking visit. The sensitivity of S. albumin, uric acid and creatinine area is 50%, 10%, 0%. Specificity of serum albumin is 5.25%, uric acid is 9.09%. But specificity of creatinine is high (97%) positive predictive value of all parameters are low. PPV of serum albumin is 4.76%, serum creatinine is 6.6%. Negative predictive value of creatinine is high (72%). Negative predictive value of serum albumin and serum uric acid are 6.42% and 9.12% respectively. Conclusion: In developing nations, pre-eclampsia is a common cause of maternal and neonatal illness. In maternal serum, many biochemical markers of pre-eclampsia have been identified. Uric acid, creatinine, and albumin are only a few of them. Uncorrelated serum uric acid, serum creatinine, or serum urea readings are insufficient to be considered as reliable predictors of preeclampsia.