Abstract
Radix Bupleuri (RB), also named Chaihu in Chinese, is a commonly used herbal drug in traditional Chinese medicine (TCM), and the processing of RB with vinegar to prepare vinegar-baked Radix Bupleuri (VBRB) has a long history in the clinic of TCM. In the present study, GC-MS coupled with multivariate data analysis was applied to compare the volatile components between crude and two vinegar processed RBs. After vinegar baking, the oil yields were decreased significantly, and the chemical compositions were also changed greatly. The chemical changes included the disappearance or appearance, as well as the content increase or decrease of some volatile compounds. The oil yields of two different VBRBs showed no significant difference but differed markedly in their chemical compositions, suggesting that the type of vinegar exerted great impacts on the vinegar-baking process. Thus, the effect of different vinegars on processing should be further investigated to ensure the therapeutic effect and safety of VBRB in clinic.
Highlights
Radix Bupleuri (“chaihu” in Chinese, short for RB), the dry root of Bupleurum chinense DC. or B. scorzonerifolium Willd. (Apiaceae), is a commonly used herbal drug in traditional Chinese medicine (TCM) and plays an important role in the treatment of many diseases such as influenza, fever, malaria, hepatitis, jaundice, nephritis, dizziness, lung diseases, cancer, and menstrual disorders in China, Japan, and other Asian countries [1,2,3,4]
Processing of herbal drugs has been a part of the heritage of Chinese medicine for thousands of years; it plays an important role in disease prevention and control for the Chinese people and ensures the safe and effective clinical treatment of TCM [7]
When RB is mixed with vinegar and baked to dry, it is changed to vinegar-baked Radix Bupleuri (VBRB)
Summary
Radix Bupleuri (“chaihu” in Chinese, short for RB), the dry root of Bupleurum chinense DC. or B. scorzonerifolium Willd. (Apiaceae), is a commonly used herbal drug in traditional Chinese medicine (TCM) and plays an important role in the treatment of many diseases such as influenza, fever, malaria, hepatitis, jaundice, nephritis, dizziness, lung diseases, cancer, and menstrual disorders in China, Japan, and other Asian countries [1,2,3,4]. (Apiaceae), is a commonly used herbal drug in traditional Chinese medicine (TCM) and plays an important role in the treatment of many diseases such as influenza, fever, malaria, hepatitis, jaundice, nephritis, dizziness, lung diseases, cancer, and menstrual disorders in China, Japan, and other Asian countries [1,2,3,4]. Processing of herbal drugs has been a part of the heritage of Chinese medicine for thousands of years; it plays an important role in disease prevention and control for the Chinese people and ensures the safe and effective clinical treatment of TCM [7]. After being processed with vinegar, both the yields [16, 17] and compositions [18] of volatile oil in Radix Bupleuri could be changed. There are many kinds of vinegars present in the Chinese market, and most of them
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