Comparison of Tissue-Link combined with Cusa and Pringle in hepatectomy for primary hepatocellular carcinoma

Abstract

Objective To evaluate the clinical effect of Tissue-Link combined with Cusa and Pringle in hepatectomy for primary hepatocellular carcinoma. Methods From January 2013 to January 2017, the clinical data of ninety-six primary hepatocellular carcinoma patients who had received hepatectomy were collected.45 cases of hepatectomy (control group) were performed by Pringle.The other 51 cases (observation group) were treated with Tissue-Link combined with Cusa.The indexes and survival rates were compared between the two groups during and after operation. Results Compared with the control group, the operation time of the observation group was prolonged ((189.2±45.8) min vs.(151.6±34.7) min, t=-5.101), the intraoperative blood loss ((273.5±141.6) ml vs.(371.3±127.2) ml, t=7.396), total bilirubin at seventh days after the operation ((15.7±8.9) μmol/L vs.(26.5±10.8) μmol/L, t=5.320) and postoperative albumin supplementation((61.0±9.7) g vs.(84.6±9.3) g, t=7.698) of the observation group decreased.The tumor recurrence rate (0 vs.8.9% (4/45)), intrahepatic metastasis rate (7.8% (4/51) vs.20% (9/45)), extrahepatic metastasis rate (3.9% (2/51) vs.17.8% (8/45)) (χ2=.031, 6.315, 6.746) decreased and the differences were statistically significant (P<0.05). The 2 year and 3 year tumor free survival rate (88.2%, 76.5%) of the observation group was higher than those of the control group (64.4%, 44.4%, χ2=5.468, 8.902), and the total survival rate of 3 year after operation (80.4%) in the observation group was significantly, higher than that of the control group (51.1%, χ2=4.896), the difference was statistically significant (P<0.05). Conclusion Tissue-Link combined with Cusa is superior to Tissue-Link combined with Pringle in hepatectomy for primary hepatocellular carolnoma.It has less intraoperative blood loss, less damage to liver function and a lower relapse rate of ineisional margin, and the disease-free survival rate and overall survival rate are improved significantly. Key words: Primary hepatocellular carcinoma; Hepatectomy; Tissue-Link; Cusa