Abstract
8024Background: Collection efficiency (CE) of an apharesis machine refers to the proportion of cells passing through it that is harvested. A higher collection efficiency reduces the need for repeated apharesis sessions and is a good measure for comparison of individual machines. Methods: Patients who underwent first harvest after G-CSF mobilization between Jan 2014 and Sept 2015 were included in the study. G-CSF was given at 10mcg/kg/day for 4 days and harvest was started from d5. Peripheral blood CD34 (PBCD34) counts were enumerated on d4. The 3 apharesis machines used were Haemonetics MCS+, Fresenius Com.Tec and Cobe Spectra. Standard volume apharesis (2-3 times patient blood volume) with recommended MNC protocols were employed. CE (as%) is calculated as total number of CD34+ cells collected×10-4 divided by D4-PBCD34/µL×blood vol. processed (lt). Oneway ANOVA with post hoc analysis was used to compare CE of individual machines. Simple logistic regression was used to look for peri-apharesis factors which...
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