Comparison of the predictive values of CRP, CRP/albumin, RDW, neutrophil/lymphocyte, and platelet/lymphocyte levels in determining the severity of acute pancreatitis in patients with acute pancreatitis according to the BISAP score.

Abstract

In our study, it was aimed to find out whether it would be possible to determine the disease severity by comparing the values of red cell distribution width (RDW), c-reactive protein (CRP), CRP/albumin, neutrophil/lymphocyte ratio (NLR), and platelet/lymphocyte ratio (PLR) in patients with acute pancreatitis according to Bedside Index of Severity in Acute Pancreatitis (BISAP) scores at the time of admission. Five hundred patients diagnosed with acute pancreatitis were included in the study. According to BISAP scores, 388 (77.6 %) patients were evaluated as having mild acute pancreatitis and 112 (22.4 %) patients as having severe acute pancreatitis. In ROC analysis, values of 70.54 % sensitivity and 70.10 % specificity for CRP, 71.43 % sensitivity and 70.88 % specificity for CRP/albumin, 80.36 % sensitivity and 30.30 % specificity for RDW, 75.00 % sensitivity and 43.98 % specificity for NLR, and 55.36 % sensitivity and 38.51 % specificity for PLR were determined. Values of 85.71 % sensitivity and 66.49 % specificity were determined for the NLR-CRP/Albumin-RDW 2** score as a newly created scoring system. CRP/albumin, NLR, PLR, and RDW values ​​were found to be statistically significantly higher in patients with severe acute pancreatitis compared to those with mild acute pancreatitis according to the BISAP score (pthat this scoring system could be a practical and reliable guide in the treatment and follow-up of patients with acute pancreatitis (Tab. 6, Fig. 3, Ref. 22).