THE COMBINATION OF PLR - NLR AND BISAP IN THE PROGNOSIS OF ACUTE PANCREATITIS AT CHO RAY HOSPITAL

Abstract

Background: Acute pancreatitis (AP) is an inflammatory process in which the local pancreatic injury leads to systemic inflammation. Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) have been shown to predict the severity of various diseases related to inflammation. Data about prognostic value of the combination of PLR - NLR and Bedside index of severity in acute pancreatitis (BISAP) score in patients with AP was still limited. This study aimed to investigate the prognostic value of the combination of PLR - NLR and BISAP scorein patients diagnosed with AP and its relationship with the severity of the disease. Methods: A prospective cross-sectional study. Results: The study records a total of 132 patients being enrolled from February 2019 to September 2019 at the Gastrointestinal Department and Intensive Care Unit of Cho Ray Hospital with AP due to alcohol use (n = 42), gallstone (n = 12) and hypertriglyceridemia (n=36). Patients with PLR ≥ 375.55 and/or NLR ≥ 12.46 had a higher rate of severe AP compared to those with PLR < 375.55 and NLR < 12.46 (OR 2.619, 95% CI: 1.206- 5.686, P 0.013). The combination of PLR - NLR and BISAP demonstrated a predictive value of severe AP (AUC 0.667, 95% CI: 0.579-0.748) with sensitivity being 65.7%, specificity being 67.7%, PPV being 43.4% and NPV being 84.0%. Conclusion: Our study demonstrated that the combination of NLR - PLR and BISAP can predict the severity of acute pancreatitis Key words: Acute pancreatitis (AP), Neutrophil to lymphocyte ratio (NLR), Platelet to lymphocyte ratio (PLR), Severity, BISAP score