Abstract
Comparison of the live attenuated mumps vaccine (Miyahara strain) with its preattenuated parental strain
Highlights
IntroductionContagious vaccine-preventable disease caused by the mumps virus (MuV)
Mumps is an acute, contagious vaccine-preventable disease caused by the mumps virus (MuV)
Live attenuated MuV vaccines have been developed by adapting the virus for different species of host or for different conditions of temperature, after repeated trial and error
Summary
Contagious vaccine-preventable disease caused by the mumps virus (MuV). A mumps epidemic occurs every 3 to 5 years in unvaccinated populations, and humans are the only natural host for MuV infection. MuV is transmitted by the respiratory route and replicates primarily in the nasal epithelium, leading to viremia, and it triggers secondary viral replication [1]. Up to 30% of MuV infections are asymptomatic or show only nonspecific respiratory symptoms. In 70% to 90% of symptomatic infections, MuV invasion of glandular epithelium results in mumps parotitis. MuV enters the cerebrospinal fluid (CSF) during the viremia. CSF pleocytosis leads to a form of aseptic meningitis that occurs in about 10% of mumps cases. More serious complications, such as deafness and encephalitis, occur at a low frequency [1]
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