Comparison of the efficiency of sulodexide, ginaton and valsartan treatment on microalburninuria in patients with metabolic syndrome

Abstract

Objective To observe the efficiency and safety of sulodexide,ginaton and valsartan on microalbuminuria in patients with metabolic syndrome. Methods Ninety patients suffered from metabolic syndrome combined with microalbuminuria were randomly divided into 3 groups. Patients in group SG (n = 30) were treated by injecting sulodexide,in group GG (n =30) injecting ginaton,and in group VG (n =30)taking valsartan tablets. The levels of urinaty albumin excretion rates ( UAER), platelet aggregation ratio (PAR) ,fibrinogen and high sensitivity c-reactive protein (hs-CRP) were detected before and after 4 weeks on corresponding therapy. Results UAER and hs-CRP decreased significantly in all patients of the three groups ( P ＜ 0.001 ). Furthermore, the levels of UAER and hs-CRP in group SG and GG were even more lower than those in group VG (P ＜0.01 ) ,and UAER was significantly correlated to with hs-CRP. After treatment, PAR and fibrinogen levels in group SG and group GG were significantly lower than those in baseline (P ＜0.05). The liver function showed no significant difference before and after treatment in three groups (P ＞0.05). Conclusions Compared with valsartan, sulodexide and ginaton are more efficient in reducing UAER in patients with metabolic syndrome,which may be due to their capability to inhibit systemic inflammation, platelet aggregation, and plasma fibrinogen. Key words: Metabolic syndrome; Sulodexide; Ginaton; Valsartan; Microalbuminuria; hs-CRP