Comparison of the efficacy and safety between dezocine injection and morphine injection for persistence of pain in Chinese cancer patients: a meta-analysis

Lei Wang,Xudong Liu,Jianfeng Wang,Guozhuan Zhang,Lishuang Liang,Yingjiao Sun

doi:10.1042/bsr20170243

Abstract

The association between the efficacy and safety of dezocine injection and morphine injection for persistence of pain in patients with cancer had yielded controversial results. Therefore, we conduct a meta-analysis of existing observational published studies to assess the relationship between them among Chinese. We conducted a comprehensive research from the databases of PubMed, Web of Science, and Wan Fang Med Online for the related studies up to October 2016. Summary odds ratio (OR) with 95% confidence interval (95% CI) were calculated with the random effects model. Nine published studies comprising 333 dezocine injection patients and 321 morphine injection patients were included in this meta-analysis. Our results suggested that there was no statistical significance between dezocine injection and morphine injection at the case number of effective pain relief (EPR) [OR = 0.97, 95% CI (0.77–1.22), I2 = 0.0, P for heterogeneity = 1.000]. However, the rate of adverse drug reaction (ADR) caused by dezocine injection was 56% less than that caused by morphine injection, the difference was statistically significant [OR = 0.44, 95% CI (0.30–0.65), I2 = 0.0, P for heterogeneity = 0.980]. No between-study heterogeneity and publication bias were found. In conclusions, this meta-analysis indicates that there is no significant association on the efficacy of persistence of pain in patients with cancer between dezocine injection and morphine injection among Chinese. However, dezocine injection was with less ADR compared with morphine injection.

Highlights

In recent years, with the development of medical technology, the survival of cancer patients has been significantly extended, and the life quality of cancer patients had been caused more and more attention
We conducted a meta-analysis to assess if dezocine injection was more effective and safe for persistence of pain in patients with cancer compared with morphine injection
The inclusion criteria were as follows: (1) the study type was cohort, case–control, randomized controlled trial, or cross-sectional design; (2) the exposure of interest was using dezocine injection or morphine injection for persistence of pain in patients with cancer; (3) the outcome of interest was the case number of effective pain relief (EPR) or the numbers of adverse drug reaction (ADR); (4) the study reported the country in China; (5) the study should be written in English or Chinese

Summary

Introduction

With the development of medical technology, the survival of cancer patients has been significantly extended, and the life quality of cancer patients had been caused more and more attention. Pain is one of the most common and most intolerable symptoms of cancer patients and a major factor in the quality of life. A previous publication found that dezocine was a promising and safe analgesic that was slightly more potent than morphine for the relief of perioperative pain [4]. The association between the dezocine injection and morphine injection for persistence of pain in patients with cancer has yielded controversial results. We conducted a meta-analysis to assess if dezocine injection was more effective and safe for persistence of pain in patients with cancer compared with morphine injection

Methods

Results

Conclusion