Comparison of the effects of virus inactivation of plasma and albumin in plasma exchange liquid gallinger therapy on the treatment of severe systemic lupus erythematosus

Abstract

Objective To compare the clinical curative effect of virus inactivating activity of plasma and albumin compound sodium chloride injection in liquid plasma exchange(PE)for treatment of severe systemic lupus erythematosus(SLE). Methods A total of 75 cases of severe SLE patients were randomized according to the number table method patients for virus inactivation of plasma group A(37 cases)and liquid albumin plasma group B(38 cases). The changes of immunoglobulin protein(IgG,IgA,IgM),ESR, complement C3,C-reactive protein(CRP), blood urea nitrogen(BUN)and serum creatinine(CR)index in the two groups were observed before and after PE. Clinical SLE-DAI(systemic lupus erythematosus disease activity index)score changes, adverse reactions occurred rate and clinical efficacy of two groups were compared. Results After treatment of group A was treated with PE,laboratory indicators except IgM(t＝0.509,P＝0.612), other indexes were significantly decreased, differences were statistically significant (t＝29.447,186,56.447,41.867,12.841,92.675,92.980,all P＜0.01). In group B,the IgM,IgA,CRP,C3 and preoperative showed no statistical significance(t＝0.565,1.165,0.902,all P＞0.05), while IgG and ESR, bun, crea and replacement of the differences have statistical significance(t value were 28.999,194.9,40.634,40.634104.918,P value＜0.01). Ttotal efficiency of group A was 91.9%, the average clinical SLEDAI score was(9.4± 1.2)points, total efficiency of group B was 77.3%, clinical SLEDAI score was(13.8±1.1)points and the difference between the two groups were statistically significant(χ2＝8.831,t＝15.560,P＜0.01). In group A, the adverse reaction rate was 15.3%,that of group B was 16.2%, there was no significant difference between the two groups(χ2＝0.509,P＞0.05). Conclusion The clinical curative effect of virus inactivation of plasma replacement solution in treatment of severe SLE is better than that of albumin by Ringer's solution. Key words: Replacement fluid; Plasma exchange; Systemic, lupus erythematosus