Abstract

Objective To evaluate the effects of atorvastatin 10 mg or simvastatin 20 mg on serum lipids and high sensitive C-reactive protein (hs-CRP) in Tibetan type 2 diabetic patients with dyslipidemias.Methods Seventy Tibetan type 2 diabetic patients with dyslipidemias were divided into two groups by random number table: atorvastatin 10 mg group(35 cases,treated with atorvastatin 10 mg/d) and simvastatin 20 mg group (35 cases, treated with simvastatin 20 mg/d). Before and 4 weeks after treatment, total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), triglyceride (TG), apolipoprotein B (ApoB), white blood cell (WBC) count, fasting blood glucose (FBG) and hs-CRP were measured and adverse reactions were observed. Results After treatment for 4 weeks, the levels of TC, LDL-C and ApoB were significantly decreased in two groups (P＜ 0.01 ), and the level of TG was significantly decreased in atorvastatin 10 mg group [( 1.39 + 0.63 ) mmol/L vs. ( 1.95 ±1.62) mmol/L,P＜0.05], but was not significantly decreased in simvastatin 20 mg group [(1.72 ±0.32)mmol/L vs. ( 1.93 ± 0.83 ) mmol/L,P ＞ 0.05]. The level of hs-CRP was significantly decreased in two groups (P ＜ 0.05), and the decreased range in atorvastatin 10 mg group was higher than that in simvastatin 20 mg group (40.51％ vs. 35.34％ ,P ＜ 0.05). Stepwise regression analysis showed that the decreased hs-CRP was independent of reduced serum lipids and had relationship with the kinds of statins (B =-0.384,P=0.022).Conclusions The effects of simvastatin on serum TC, LDL-C are the same as atorvastatin. Both have significant anti-inflammatory effects, while the degree of hs-CRP reducing by atorvastatin 10 mg is higher than that by simvastatin 20 mg in Tibetan type 2 diabetes. Key words: Dyslipidemias; Zang nationality; C-reactive protein; Atorvastatin; Simvastatin

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