Comparison of the effects of Anesthesia Methods on Dynamic Thiol/Disulfide Homeostasis in Patients with Chronic Obstructive Pulmonary Disease Under Surgical Stress

Abstract

Purpose: Chronic Obstructive Pulmonary Disease (COPD) is linked to increased oxidative stress. Changing oxidative stress status due to anesthesia applications may affect surgical stress and the incidence of postoperative complications.
 This study aims to contrast the impacts of general anesthesia (GA) and spinal anesthesia (SA) on the dynamic thiol-disulfide homeostasis among patients with COPD who are undergoing inguinal hernia surgery.
 Materials and Methods: As per the 2017 Global Strategy Report for the Diagnosis, Management, and Prevention of COPD, patients with airflow obstruction (50% ≤ FEV 1 < 79%) and FEV1/FVC < 0.7 were evaluated. A total of 52 COPD patients, group GA (n= 26) and group SA (n= 26), who were scheduled for inguinal hernia surgery, were included in this observational study. Blood specimens were collected during the preoperative period and at the postoperative 24th hour. Parameters of thiol/disulfide homeostasis were analyzed.
 Results: Both in the GA group and the SA group, a decrease in total thiol, native thiol, and disulfide values was observed after anesthesia compared to before anesthesia. However, only in Group SA, the decrease in post-anesthesia total thiol (p