Abstract
There are several possibilities for repairing a nerve defect. These include nerve grafting, tissues for bridging, biological or synthetic nerve conduits. Such conduits, alone or filled with different tissues or substances, may be the key for a major breakthrough in the modern treatment of nerve defects. The easiest way to research these new methods is by experimental in vivo research on live animals – such as the Wistar rats. The following article aims to compare 4 different types of repairs for nerve defects: the nerve graft, a biologic nerve conduit (rat aorta), rat aorta with platelet rich plasma and rat aorta with stem cells.
Highlights
There are several possibilities for repairing a nerve defect
The 4 methods considered for comparison were: 1. 1st lot - nerve allograft 2. 2nd lot – simple vascular conduct – rat aorta 3. 3rd lot – rat aorta filled with platelet rich plasma (PRP) 4. 4th lot – rat aorta filled with mesenchymal stem cells
42 male rats were used for the study. 2 were sacrificed in order to harvest biologic materials (PRP and aortic conduits)
Summary
There are several possibilities for repairing a nerve defect These include nerve grafting, tissues for bridging, biological or synthetic nerve conduits. The following article aims to compare 4 different types of repairs for nerve defects: the nerve graft, a biologic nerve conduit (rat aorta), rat aorta with platelet rich plasma and rat aorta with stem cells. Experimental nerve microsurgery represents a real challenge, not because it is hard to perform, but rather because the results can be tardily acknowledged This implies a great deal of effort, as the results must be measured in dynamics, at different intervals of time, in order to point out a precise moment of recovery. Considered to be golden standard, there are other possibilities for replacing the nerve graft in order to bridge nerve gaps These include different types of conduits – either biologic or synthetic. To improve the outcomes by increasing the speed of nerve regeneration, several biological substances or tissues have been used in different experiments - degenerated muscles, adipose tissue or platelet rich plasma[3-5]
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