Abstract
(J. Extra-Corpor. Technol. 79(2) p. 209–215, Summer 1987, 47 refs.) Seventy-three patients undergoing cardiopulmonary bypass (CPB) were prospectively randomized into two groups to compare the effect of membrane (Terumo hollow-fiber [MO]); versus bubble (Harvey 1500 [BO]) oxygenation on red blood cell (RBC) deformability. Comparison of blood trauma was done by measuring the red cell filtration rate (RFR) which reflects changes in RBC deformability. In patients with a high (> 30 ul/sec) RFR before CPB, the M0-1 subgroup showed significantly (p < 0.05) lower reductions of RFR during CPB compared to the B0-1 subgroup. In patients with a low (< 30ul/sec) RFR before CPB, the M0-2 subgroup showed a significantly (p < 0.01) lower loss of RFR compared to the B0-2 subgroup. The use of blood gas-estimations also revealed that hyperoxia was more frequent in the BO group. The frequency of normal pO2 levels (75-97 mmHg) at 30 min., 60 min. and 90 min. of CPB in the MO group was 65%, 43% and 77% compared to 22%, 11% and 11% (p < 0.01) respectively in the BO group. The earliest significant RFR differences between the MO and BO groups could be detected at 30 minutes of CPB; differences in plasma hemoglobin reached significance after one hour of CPB. This study demonstrates a greater deleterious effect on red blood cells when a BO is used for CPB.
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