Abstract
Results of 10 biochemical tests of 172 patient data (among them 84 men data and 88 women data, resp.) before and after administration of statins were thoroughly studied. All monitored patients are characterized by disorders of lipoprotein metabolism or other kind of dislipidaemia. The calculations were performed using four chemometrical methods facilitating quantification and visualization of the statin effect upon most important biochemical parameters, mainly lipid markers, and allowing classification of the patient blood samples taking into account whether the patient has been or has not been medicated by a statin drug.
Highlights
At the present state of medicine the patients with Coronary Heart Disease (CHD) may require intensive drug therapy usually realized by hypolipidemic drugs like statins
Several statistical/chemometrical tools have been here newly applied: (a) the box-plot representation of the statin drug effect, (b) the comparison of efficiency of the selected variables by means of receiver operating characteristic curves (ROC) analysis and Gini indices, (c) one-way analysis of variance (ANOVA) demonstrating whether the selected variable is significantly changed with the statin administration, (d) the K-th nearest neighbour (KNN) pattern recognition technique used for classification of the patient samples before and after statin administration
Serum level of the selected biochemical tests was analytically determined for 172 probands who were characterized by failure of their lipoprotein metabolism or another kind of lipidaemia
Summary
At the present state of medicine the patients with Coronary Heart Disease (CHD) may require intensive drug therapy usually realized by hypolipidemic drugs like statins. The most widely prescribed medications in patients with hyperlipidaemia and coronary heart disease, have a number of pleiotropic actions beyond cholesterol lowering. They improve endothelial function, they have antioxidant and anti-inflammatory effects, they regulate neovascularization and have immunomodulatory activities (KWAK et al, 2003; TOUSOULIS et al, 2007; BLUM et al, 2009). Further techniques of laboratory data processing were applied to inspect a diverse influence of the statin administration upon blood serum levels of the selected biochemical parameters. This, rather complex approach allows investigate the statin effects on the patient’s status from a different point of view
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