Abstract
e14661 Background: We studied comorbidity and other survival predictors for patients (pts) with CRC and compared the pts of different races. Methods: In an IRB-approved protocol, we reviewed the records of pts diagnosed with CRC at a VA medical center from 01/01/2003 to 12/31/2011 for demographics, stage, grade, ECOG performance status (PS), CEA, hemoglobin (HGB), and albumin (ALB) at diagnosis (dx). Comorbidity was assessed with the Charlson Comorbidity Index (CCI), the Cumulative Illness Rating Scales (CIRS), and the Kaplan-Feinstein Index (KFI). Statistical analyses were performed with SAS 9.2/Stata 11.0. We compared the pts by race groups Caucasian (C) vs African American (A). Results: There were 279 men. 156 pts (55.9%) were race C, 106 pts (38%) race A, 15 pts (5.4%) Hispanics, and 2 pts (0.7%) Asians. The median (M) age at dx was 70 (45-90) years. 132 pts (47.3%) were deceased. Age, grade, stage, ECOG PS, HGB, ALB, and CEA were similar between group A and C. In group A, M CCI is 4.2 (0.8-14), M CIRS 15 3.0 (0-5), M CIRS16 5 (0-13), M CIRS17 2 (0-6), M CIRS18 0 (0-1), M CIRS 19 0 (0-1), M KFI 2 (0-3). In group C, Median (M) CCI is 4.2 (0.4-19.6), M CIRS15 3.0 (0-6), M CIRS16 6 (0-13), M CIRS17 2 (0-13), M CIRS18 0 (0-1), M CIRS 19 0 (0-1) and M KFI 2 (0-3). By univariate analysis, for group A, grade, stage, ECOG PS, HGB, CCI, CIRS16, CIRS 19 and KFI are significant predictors. For group C, age, grade, stage, ECOG PS, HGB, ALB, and CIRS16 are significant predictors for survival. Summary for significant multivariate predictors are shown in the Table. Conclusions: This study from a larger population confirms our earlier findings (ASCO 2012 e14125). Grade, stage, ECOG PS, and CIRS 19 are independent survival predictors for veterans with CRC. Age, stage, ECOG PS, ALB and CIRS19 are independent predictors of survival for group C pts with CRC. Grade, stage, ECOG PS, and CIRS19 are predictors for group A pts with CRC. This variation may suggest biological difference between races. More studies are needed to confirm this. Supported by NJCCR. [Table: see text]
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