Comparison of stress response in patients of different ABO blood group

Abstract

Objective To compare the stress response in patients of different ABO blood group.Methods Sixty patients of blood group A, B, AB and 0 (15 in each blood group), aged 30-50 yr, weighing 50-70 kg, scheduled for surgeries under general anesthesia were divided into 4 groups according to the blood group: group A, group B, group AB and group 0. The patients were premedicated with intramuscular scopolamine 0.3 mg. Anesthesia was induced with iv infusion of midazolam 0.05 mg/kg, propofol 1 mg/kg, fentanyl 4 μg/kg and succinylcholine 1.5 mg/kg. The patients were mechanically ventilated after tracheal intubation. BIS was maintained at 40-50. Anesthesia was maintained with iv infusion of propofol at 100μg·kg~(-1)·min~(-1) and remifentanil at 0.2 μg·kg~(-1)·min~(-1) and intermittent iv boluses of vecuronium 0.08 mg/kg. MAP and HR were monitored and recorded before induction of anesthesia (baseline, T_0) and at 0, 1, 5 and 10 min after tracheal intubation (T_(1-4) ) . Central venous blood samples were taken simultaneously to determine the plasma concentrations of epinephrine, norepinephrine and dopamine. Results The increasing amplitude in MAP, HR and plasma concentrations of epinephrine, norepinephrine and dopamine was significantly decreased in group B, AB and 0 compared with group A, and in group B and O compared with group AB (P 0.05 ) . Conclusion The stress response is the strongest in the patients of blood group A, followed by blood group AB and then blood group B and O. Key words: ABO blood-group system; Stress