Effect of ABO blood group factor on anticoagulation with aspirin

Abstract

Objective To evaluate the effect of ABO blood group factor on anticoagulation with aspirin. Methods Seventy-three patients of both sexes, aged 45-70 yr, who did not take aspirin recently, were divided into 4 groups according to the blood group: blood group A group (group A, n=18), blood group B group (group B, n=20), blood group AB group (group AB, n=15), and blood group O group (group O, n=20). Aspirin 100 mg/d was taken orally for 2 weeks.Fasting blood samples were taken from the peripheral vein before administration (T1) and at 2 weeks after administration (T2) for measurement of activated partial thromboplastin time (APTT), thrombin time (TT), prothrombin time (PT), fibrinogen (Fib), platelet count (Plt) and platelet aggregation rate. Results There was no significant difference in Plt at T1, 2 or platelet aggregation rate at T1 among the four groups (P>0.05). Compared with A, B and AB groups, PT, APTT and TT were significantly prolonged and Fib was decreased at T1, and platelet aggregation rate was decreased at T2 in group O (P 0.05), and platelet aggregation rate was significantly decreased at T2 in the four groups (P<0.05). Conclusion ABO blood group factor is related to the individual variation in anticoagulation with aspirin, patients of A, B and AB blood group have the same sensitivity to anticoagulation with aspirin, and patients of O blood group are more sensitive to anticoagulation with aspirin. Key words: ABO blood group system; Aspirin; Platelet aggregation