Comparison of some diabetic and oxidative status parameters in three different experimental type 2 diabetic rat models

Abstract

The aim of the study was to compare the levels of postprandial glucose, oral glucose tolerance test, and malondialdehyde parameters in 3 different experimental type 2 diabetic models induced rats. In the study, 18 Wistar albino rats were divided into 3 groups. The high-fat diet and streptozotocin (35 mg/kg, SC) were administered to the rats in the first group, water containing 20% fructose was administered to the second group, and nicotinamide (110 mg/kg, IP) and streptozotocin (60 mg/kg, SC) were administered to the third group. Oral glucose tolerance test, postprandial glucose, and malondialdehyde analyzes in 3 different experimental type 2 diabetic rat models were performed and they were euthanized at the 70th days. The postprandial glucose level was higher in the 1st and 3rd model groups than in the 2nd model group, while malondialdehyde level was no difference between the groups. Moreover, the second model group was significantly lower than the other two groups at all times according to oral glucose test results. In conclusion, the results of this research will contribute to researchers choosing the right model and parameters in experimental type 2 diabetic models in rats in the future.