Abstract
1. 1. Comparisons of calcium levels in heart, skeletal muscle, brain, liver and plasma were made throughout the life spans of normal and genetically myopathic hamsters. 2. 2. A large calcium accumulation occurred in, and was restricted to, myopathic tissues (heart and skeletal muscle). 3. 3. Calcium elevation in myopathic tissues corresponded to documented lesion appearance, and persisted throughout the remainder of the life span. 4. 4. Calcium buildup in heart and skeletal muscle, as a central feature of the myopathic process, does not reflect a general failure of calcium homeostasis; nonmyopathic tissues are unaffected. 5. 5. Calcium increased moderately in some normal tissues late in life.
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