Abstract
Sensitivity and specificity of Carcinoembryonic Antigen (CEA), Tissue Polypeptide Antigen (TPA), and CEA X TPA product values were analysed after simultaneous determination of these tumor-associated antigens in plasma of patients with active cancer and healthy individuals as a control. There were different sensitivities for each of the markers or marker product values with respect to tumor localisations. At a level of 90 % sensitivity CEA was most sensitive for breast cancer, followed by malignancies of the lung, the gastrointestinum, the urinary bladder, the thyroid, the testis. TPA showed highest sensitivity for cancer of the urinary bladder and breast cancer, followed by gastrointestinal, testicular, lung, and thyroid cancer. CEA and TPA product values showed in some of the cases increased sensitivity when compared with single marker determinations of CEA or TPA.
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