Abstract
BACKGROUND: Silver nanoparticles are widely used in various types of industry, but their safety for humans has not been strictly proven. The experimental data currently available on the comparison of the toxic effect of silver nanoparticles and AgNO3 are contradictory and the question of the priority use of silver nanoparticles remains open, especially for organisms with impaired copper metabolism. AIM: The main aim of this study is to compare the effects of silver nanoparticles and AgNO3 on the nematode with normal and impaired copper metabolism and draw conclusions about their toxicity. MATERIALS AND METHODS: In this work, we determined the sublethal concentration (LC50) of AgNPs and AgNO3 for H828Q nematode strain. Using the results obtained, we performed the development assay, thrashing assay and lifespan analysis of the animals. RESULTS: It has been shown that LC50 of silver nanoparticles is lower than the one for AgNO3. Caenorhabditis elegans with impaired copper metabolism treated with silver nanoparticles have a statistically significant reduction in development, level of mobility and lifespan, comparing to animals treated with AgNO3. CONCLUSIONS: The results obtained allow us to conclude that the toxic effect of silver nanoparticles on C. elegans with a genetic defect in copper metabolism is higher comparing to ionic silver.
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