Abstract
Due to the widespread use of MTA in dentistry and various brands of this product, we decided to compare the three brands available in the country market by their biocompatibility. We divided 20 male Wistar rats into four groups. After local anesthesia and washing, we made two incisions on both sides (4 incisions in total). The experimental groups were Angelus MTA (Angelus, Brazil), BioMTA (CERKAMED, Poland), Root MTA (Dr. Lotfi, Tabriz, Iran), and the control group. The resulting paste was placed in a tube and implanted subcutaneously into male Wistar rats. Wistar rats were sacrificed 7, 15, 30, and 60 days later, with high anesthetic doses. The sample implanted in 10% formalin was stabilized after tissue processing and H&E staining under a microscope. The inflammatory reaction in the tissues received different scores at the beginning of the tube opening. BioMTA had the highest inflammatory response among the groups, but the difference was not statistically significant (p > 0.05). Also, there was no significant difference between the groups' granulation and calcification (p < 0.05). There was a significant difference between BioMTA, Angelus MTA, Root MTA, and control groups in fibrous capsule formation (p < 0.05). Angelus MTA showed the lowest mean fibrous capsule formation in all periods. The effects of Angelus MTA, Root MTA, and BioMTA on connective tissue were investigated and compared. According to this study, these materials have good biocompatibility. According to the findings and statistical analysis, Angelus MTA has the most biocompatibility.
Highlights
Due to the widespread use of Mineral Trioxide Aggregate (MTA) in dentistry and various brands of this product, we decided to compare the three brands available in the country market by their biocompatibility
Due to the importance of biocompatibility of materials used in dentistry and the lack of a similar study, we decided to compare the biocompatibility of domestic samples including Root MTA, BioMTA, and Angelus MTA
E BioMTA group showed a mild-to-moderate response after 7 days. e inflammatory response was lowered after 15 and 30 days, and there was no response at 60 days. e Root MTA group showed mild-to-moderate inflammatory reactions on days 7 and 15 after surgery. is postoperative response was lowered to mild at 30 days and no response at 60 days
Summary
Due to the widespread use of MTA in dentistry and various brands of this product, we decided to compare the three brands available in the country market by their biocompatibility. Ere was a significant difference between BioMTA, Angelus MTA, Root MTA, and control groups in fibrous capsule formation (p < 0.05). MTA induces the repair of periradicular hard and soft tissues [11] It plays an essential role in optimal tissue reactions without multiple inflammatory responses, the formation of fibrous capsules, and induction of mineralized repair tissue formation [12]. BioMTA (CERKAMED, Poland) has recently been introduced to the Iranian market, which has a lower setting time, maximum plasticity, three times higher hardness, and complete biocompatibility It consists of hydroxyapatite and nanoparticles in its structure [13]. It includes hydroxyapatite and nanoparticles in its structure. Various domestically made MTAs, e.g., Lotfi Company (Root MTA, Tabriz, Iran), are affordable and always attract dentists’ attention. is study aimed to compare rat connective tissue response to BioMTA, Angelus MTA, and Root MTA
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