Comparison of Quality Of Life in Thalassemia Major Patients with Injectable and Oral Iron Depletion

Abstract

Background: One of the reasons that reduce the satisfaction and quality of life in thalassemia is the injection of iron-depleting drugs that always cause complications in these people. But with the advent of oral detoxification drugs are predicted, this problem has improved to some extent. given that this province is one of the regions with the highest prevalence of thalassemia in Iran. Therefore, in this study, we aimed to compare the quality of life in major thalassemia patients receiving oral and injectable iron depleting drugs. Materials and Methods: This cross-sectional descriptive-analytic (Prospective) study was performed during a one-year period (2017-2018) in Ali Asghar Hospital of Zahedan University of Medical Sciences. Demographic information of patients was extracted through history as well as information in their files and recorded in information forms. EQ5D questionnaire was used to assess the quality of life. Data were analyzed using SPSS 18 software. Results: the quality of life score is significantly higher in Patients receiving oral treatment than injecting patients. (p-value:0.02) The issue is also true in terms of the degree of health of patients in both groups. (p-value:0.03) According to the study variables comparison of quality of life score and health status of patients between the two groups receiving injectable and oral iron deprivation, showed that in females, age group less than 15 years and patients with poor acceptance, the degree of health in the group receiving oral decontamination was higher than injectable decontamination. Conclusion: Quality of life in patients with thalassemia treated with oral iron depletion is higher than patients receiving injectable iron depletion treatment, and in females, age group less than 15 years, and patients with poor acceptance, this difference is significant.