COMPARISON OF PSMA PET AND MRI FOR STAGING OF PROSTATE CANCER

Abstract

PSMA PET is a recent advance used in the evaluation of prostate cancer and current literature has a paucity of studies comparing it with MRI which is extensively used for clinical evaluation of prostate cancer. The aim of this study was to compare these modalities and understand the agreement between the two for the clinical staging of prostate cancer.Study population included 72 patients referred the Urology and Uro oncology department, Amrita Institute of Medical Sciences, Kochi from June 2018 to 2021 with PSA 7 or more referred for simultaneous PSMA PET MRI. The PSMA PET results were interpreted by a nuclear medicine specialist and the MRI report was interpreted by a radiologist and TNM staging was done for both modalities. Available sextant biopsy data was collected in 43 patients. Quantitative data were expressed as mean ± SD and the qualitative data was expressed as proportions and percentages. Diagnostic measures such as sensitivity, specicity, predictive value positives, negatives and accuracy were also calculated with 95 % condence interval. A p value of <0.05 was considered to be statistically signicant. There is moderate agreement (kappa value 0.709) between MRI and PSMA PET for T staging of prostate cancer. There is strong agreement (kappa value 0.8) between MRI and PSMA PET for N staging of prostate cancer. There is strong agreement (kappa value 0.8) between MRI and PSMA PET for M staging of prostate cancer