COMPARISON OF PREGNANCY RATE AMONG DIFFERENT IVF/ICSI PROTOCOLS IN WOMEN WITH PCOS.

Abstract

Objective:To assess the pregnancy rate after using of different IVF/ICSI protocols in patients with PCOS. Study design: A total of 55 infertile women with Polycystic ovary syndrome undergoing controlled ovarian hyperstimulation for intracytoplasmic sperm injection cycle were prospectively recruited for this study in High Institute of Infertility Diagnosis and Assisted Reproductive Technology / AL-Nahrian University and Kamal AL-Samarai Hospital, center of fertility and IVF (Baghdad/Iraq) during the period from December 2015 to the end of April 2017.The fifty five PCOS women were divided into three groups: Twenty five (25) infertile women have had PCOS and young age undergone long Agonist protocol for ICSI cycle, Fifteen (15) infertile women have had PCOS who young age and have risk of OHSS (AMH > 6ng/ml or had previous history of hyper-response to ovarian stimulation protocol) undergone Antagonist protocol for ICSI and Fifteen (15) infertile women have had PCOS and age between 35-40 years old undergone short Agonist protocol for ICSI. In all patients B-HCG measure at day 14 after embryo transfer. Results:pregnancy rate was significantly higher in the PCOS patients underwent short agonist protocol (40%) compared to the PCOS patients underwent Antagonist protocol (20%) and to PCOS patients underwent long agonist protocol (16%) (P=0.0028). In this study, the percentage of pregnancy in PCOS group was (23.6%). Conclusion: It was concluded from the present study that the percentage of pregnancy was higher in polycystic ovary syndrome women more than 35 years old underwent short agonist protocol than in other ICSI/IVF protocols.