A comparison of different therapies for women with polycyatic ovary syndrome

Abstract

Objective To compare the efficacy and safety of different therapies for sterile women with polycystic ovary syndrome ( PCOS ). Methods 108 sterile women with PCOS who had had medical visits during September 2007 and July 2010 were randomized to CC group, HMG group, CC/HMG group, or LE group, 27 women for each group. Ovulation induction, follicular development, endometrial thickness, and adverse reactions were observed. Results CC group had a higher rate of ovulation but lower rate of pregnancy, thinnest endometrial thickness, and a lower multiple pregnancy rate and OHSS risks. HMG group had higher rates of ovulation and pregnancy, and highest risks of multiple pregnancy and OHSS. LE group had lower rates of ovulation and pregnancy, smallest size of follicles, and lower risks of multiple pregnancy and OHSS. CC/HMG group had higher rates of ovulation, pregnancy, multiple pregnancy, and OHSS risk. Conclusions Four therapies have positive effects on ovulation. HMG and CC plus HMG could result in a higher rate of pregnancy and higher risks of multiple pregnancy and OHSS. LE has a positive effect on the development of follicles and endometrium,but has possible teratogenicity. Key words: HMG; Polycystic ovary syndrome; Infertility; Multiple pregnancy