Comparison of plasmatic steroid levels with and without previous oral contraceptive administration in GnRH antagonist IVF cycles

Abstract

ObjectiveThe primary objective of the study was to assess the differences in plasmatic levels of oestradiol, FSH and LH in GnRH antagonist IVF cycles with or without previous oral contraceptive administration.DesignThe design of this study was prospective.Materials and methodsSeventy-five patients participated in this study. The patients were divided into 2 groups: Group I, 35 patients who were not prescribed oral contraceptives before stimulation and Group II, with 41 patients who took oral contraceptives prior to stimulation. All patients were normoresponders with normal basal FSH, LH, oestradiol and prolactin levels, normal BMI, the mean patient age was 32.67 ± 2.87. Patients with endometriosis, uterine pathology, PCO, and patients over 37 were excluded. Ovarian stimulation was initiated with 225 IU of rFSH, administering 75 IU of rLH the first day of the antagonist. The first stimulation check-up was performed on day 4 of stimulation, starting the daily administration of 0.25 mg of Cetrorelix when by sonography a ≥ 14 mm follicle was detected. When 2 or more follicles ≥17 mm were found, 10000 IU of HCG was administered and the puncture was performed 36 hours later. The embryo transfer was on day +3. Levels of FSH, LH and oestradiol were determined the theoretical day of antagonist administration (1), the following day(2) and the day of HCG adminstration(3).ResultsThe results are found in the following tables: Table 1 and Table 2. üConclusionView Large Image Figure ViewerDownload Hi-res image Download (PPT) ObjectiveThe primary objective of the study was to assess the differences in plasmatic levels of oestradiol, FSH and LH in GnRH antagonist IVF cycles with or without previous oral contraceptive administration. The primary objective of the study was to assess the differences in plasmatic levels of oestradiol, FSH and LH in GnRH antagonist IVF cycles with or without previous oral contraceptive administration. DesignThe design of this study was prospective. The design of this study was prospective. Materials and methodsSeventy-five patients participated in this study. The patients were divided into 2 groups: Group I, 35 patients who were not prescribed oral contraceptives before stimulation and Group II, with 41 patients who took oral contraceptives prior to stimulation. All patients were normoresponders with normal basal FSH, LH, oestradiol and prolactin levels, normal BMI, the mean patient age was 32.67 ± 2.87. Patients with endometriosis, uterine pathology, PCO, and patients over 37 were excluded. Ovarian stimulation was initiated with 225 IU of rFSH, administering 75 IU of rLH the first day of the antagonist. The first stimulation check-up was performed on day 4 of stimulation, starting the daily administration of 0.25 mg of Cetrorelix when by sonography a ≥ 14 mm follicle was detected. When 2 or more follicles ≥17 mm were found, 10000 IU of HCG was administered and the puncture was performed 36 hours later. The embryo transfer was on day +3. Levels of FSH, LH and oestradiol were determined the theoretical day of antagonist administration (1), the following day(2) and the day of HCG adminstration(3). Seventy-five patients participated in this study. The patients were divided into 2 groups: Group I, 35 patients who were not prescribed oral contraceptives before stimulation and Group II, with 41 patients who took oral contraceptives prior to stimulation. All patients were normoresponders with normal basal FSH, LH, oestradiol and prolactin levels, normal BMI, the mean patient age was 32.67 ± 2.87. Patients with endometriosis, uterine pathology, PCO, and patients over 37 were excluded. Ovarian stimulation was initiated with 225 IU of rFSH, administering 75 IU of rLH the first day of the antagonist. The first stimulation check-up was performed on day 4 of stimulation, starting the daily administration of 0.25 mg of Cetrorelix when by sonography a ≥ 14 mm follicle was detected. When 2 or more follicles ≥17 mm were found, 10000 IU of HCG was administered and the puncture was performed 36 hours later. The embryo transfer was on day +3. Levels of FSH, LH and oestradiol were determined the theoretical day of antagonist administration (1), the following day(2) and the day of HCG adminstration(3). ResultsThe results are found in the following tables: Table 1 and Table 2. ü The results are found in the following tables: Table 1 and Table 2. ü Conclusion