Abstract
Objectives - a comparative study of antidepressant activity and diuretic action of water and water-alcohol preparations of the fruits of Crataegus sanguinea Pall. and Crataegus submollis Sarg. Materials and methods. The study covers the water and alcohol-water extracts from the fruits of hawthorn blood-red (Crataegus sanguinea Pall.) and Quebec hawthorn (Crataegus submollis Sarg.). The comparative study of the antidepressant activity and the diuretic action of the preparations was carried out on white mongrel rats of both sexes. Results. The liquid extracts of fruits Crataegus sanguinea Pall. and Crataegus submollis Sarg. at a dose of 100 μl/kg revealed an antidepressant activity. Decoctions of Crataegus sanguinea Pall. and Crataegus submollis Sarg. at a dose of 100 μl/kg had a pronounced diuretic and saluretic activity. Pharmacotherapeutic effects of the studied preparations can be explained by the presence of flavonoids in them. Conclusion. The preparations of the fruits of Crataegus sanguinea Pall. and Crataegus submollis Sarg. can be recommended as antidepressant and diuretic agents. The fruits of Crataegus submollis Sarg. are the promising medicinal plant raw materials.
Highlights
The liquid extracts of fruits Crataegus sanguinea Pall. and Crataegus submollis Sarg. at a dose of 100 μl/kg revealed an antidepressant activity
Pharmacotherapeutic effects of the studied preparations can be explained by the presence of flavonoids in them
5. Morozova TV, Kurkin VA, Pravdivtseva OE, et al The content of total flavonoids in the fruits and shoots of some hawthorn species
Summary
Цель – сравнительное исследование антидепрессантной активности и диуретического действия водных и водно-спиртовых препаратов на основе плодов боярышника кроваво-красного и боярышника полумягкого (мягковатого). Объектами исследования служили водные и спирто-водные извлечения из плодов боярышника кроваво-красного (Crataegus sanguinea Pall.) и боярышника полумягкого (Crataegus submollis Sarg.). Отвары плодов боярышника кроваво-красного и боярышника полумягкого в дозе 100 мкл/кг характеризуются выраженной диуретической и салуретической активностью. Лекарственные препараты на основе плодов боярышника кроваво-красного и боярышника полумягкого целесообразно использовать в качестве антидепрессантных и диуретических средств. Для цитирования: Куркин В.А., Зайцева Е.Н., Авдеева Е.В., Стеняева В.В., Шайхутдинов И.Х., Жданова А.В. – д.фарм.н., профессор кафедры фармакогнозии с ботаникой и основами фитотерапии, профессор. – к.фарм.н., доцент кафедры фармакогнозии с ботаникой и основами фитотерапии. Рукопись получена: 02.10.2019 Рецензия получена: 20.10.2019 Решение о публикации принято: 24.10.2019
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