Comparison of neutrophil CD64 and C-reactive protein in the diagnosis of bacterial infection: a Meta-analysis

Abstract

Objective To compare the sensitivity and specificity of neutrophil CD64 and C-reactive protein(CRP) in the diagnosis of bacterial infection by Meta-analysis. Methods A computerized literature search of PubMed, Embase and Science Citation Index Expanded was conducted to retrieve studies related to evaluating the diagnosis value both of neutrophil CD64 and CRP in bacterial infectious diseases before January 2015.The methodological quality of each included study was assessed.The method of statistical analysis was dichotomous Meta- analysis using STATA 12.0 software. Results Ultimately we included a total of 10 studies with 1 057 specimens in neutrophil CD64 group and 1 063 specimens in CRP group.Neutrophil CD64 compared with CRP in the sensitivity, OR=1.755, 95%CI(1.041, 2.958), P=0.035, while in the specificity, OR=0.620, 95% CI(0.442, 0.870), P=0.006. Conclusion In the diagnosis of bacterial infectious diseases, neutrophil CD64 is better than CRP in the sensitivity, but, CRP is better than neutrophil CD64 in the specificity. Key words: Neutrophil CD64; C-reactive protein; Bacterial infection; Meta-analysis