Application of neutrophil CD64 on the diagnosis and treatment of infectious diseases

Abstract

The early diagnosis of serious infection is very important since the fatality rate is quite high. Traditional diagnostic methods of infection includes procalcitonin, leukocyte count, CRP and so on, of which the sensitivity and specificity is not able to achieve the early diagnosis. Recently, neutrophil CD64 has been widely concerned for the high sensitivity and specificity in early diagnosis of bacterial infection. Flow cytometry is applied to detect neutrophil CD64 in early diagnosis of infectious diseases including respiratory infection, septicemia, neonatal intensive infection, burn and postoperative infection. What's more, the sensitivity and specificity can be further improved if neutrophil CD64 was combined with other inflammatory markers. Thus, neutrophil CD64 detected by flowy cytometry plays an important role in the diagnosis, monitoring, prognosis, therapeutic effect evaluation of infectious diseases.(Chin J Lab Med, 2016, 39: 340-343) Key words: Receptors, IgG; Neutrophils; Bacterial infections; Flow cytometry