Abstract
PurposeThis study was conducted in order to compare relationships between the macular visual field (VF) mean sensitivity measured by MAIATM (Macular Integrity Assessment), MP-3, or Humphry field analyzer (HFA) and the ganglion cell and inner plexiform layer (GCA) thicknesses.MethodsThis cross-sectional study examined 73 glaucoma patients and 19 normal subjects. All subjects underwent measurements for GCA thickness by Cirrus HD-OCT and static threshold perimetry using MAIATM, MP-3, or HFA. VF and OCT in the retinal view were used to examine both the global relationship between the VF sensitivity and GCA thickness, and the superior hemiretina and inferior hemiretina. The relationship between the GCA thickness and macular sensitivity was examined by Spearman correlation analysis.ResultsFor each instrument, statistically significant macular VF sensitivity (dB) and GCA thickness relationships were observed using the decibel scale (R = 0.547–0.687, all P < 0.001). The highest correlation for the global (R = 0.682) and the superior hemiretina (R = 0.594) GCA thickness-VF mean sensitivity was observed by the HFA. The highest correlation for the inferior hemiretina (R = 0.687) GCA thickness-VF mean sensitivity was observed by the MP-3. Among the three VF measurement instruments, however, no significant differences were found for the structure-function relationships.ConclusionsAll three VF measurement instruments found similar structure-function relationships in the central VF.
Highlights
Macular visual field (VF) defects have been thought to occur in later stages, recent studies have shown to occur during the early stages of glaucoma [1,2,3]
The highest correlation for the global (R = 0.682) and the superior hemiretina (R = 0.594) Ganglion cell analysis (GCA) thickness-VF mean sensitivity was observed by the Humphry field analyzer (HFA)
The highest correlation for the inferior hemiretina (R = 0.687) GCA thickness-VF mean sensitivity was observed by the MP-3
Summary
Macular visual field (VF) defects have been thought to occur in later stages, recent studies have shown to occur during the early stages of glaucoma [1,2,3]. With the implementation of new segmentation algorithms, optical coherence tomography (OCT) can be used to visualize and measure the individual retinal layers in the macular region [6,7,8]. Using the Cirrus HD-OCT GCA algorithm (Carl Zeiss Meditec, Dublin, CA), Mwanza et al [11,12] were able to detect and measure the inner macular layers, which contained the ganglion cell layer and the IPL. When using this technique, they found there was excellent intervisit reproducibility [11,12]
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