Structure‐function relationship: Ganglion cell‐inner plexiform layer thickness by SD‐OCT and central visual field sensitivity

Abstract

AbstractPurpose To evaluate relationships between central 10‐2 visual field (VF) sensitivity by standard automatic perimetry (SAP) and the ganglion cell inner plexiform layer (GCIPL) thickness by Cirrus HD‐OCT.Methods 64 eyes: 29 control and 34 glaucomatous eyes with an isolated 10‐2 central VF defect were included. Each of them underwent analyze of GCIPL thickness by Cirrus HD‐OCT and a reproducible central VF testing (Humphrey Field Analyser, SITA standard 10‐2, Carl Zeiss Meditec). Relationship between VF sensitivity and GCIPL thickness was analysed globally and in the six sectors of the HD‐OCT‐Cirrus using Spearman rank order correlations.Results Macular VF sensitivity and GCIPL thickness relationships were statistically significant in each sector (R= 0.455 ‐ 0.576, all p<0.001). Correlation for mean macular VF sensivity and mean GCIPL thickness was higher than sectorial correlations (R=0.645, p<0.0001). For sectors analysed, the highest correlation was in inferotemporal sector (R=0.576).Conclusion GCIPL thickness by Cirrus‐HD OCT showed statistically significant structure‐function associations with central VF sensitivity. Mean central VF sensitivity had the strongest correlation.