Comparison of Low and High-dose Growth Hormone Administration on Muscle Ceramide Contents and Insulin Resistance in Rats

Hyung Lyung Jung,Sang Yeong Kim,Ho Youl Kang,Jong Sik Ryu,Young Taek Doo

doi:10.13005/bpj/1276

Abstract

Comparison of Low and High-dose Growth Hormone Administration on Muscle Ceramide Contents and Insulin Resistance in Rats

Highlights

The over the past decades, growth hormone (GH) administration has been accepted as anti–ageing, physical growth, and bone health treatments in medical clinics, and the physiological effects of GH are well presented in the literature (Doga et al 2006; Henwood et al 2002; Woodhouse et al 2006)
Plasma FFA and glucose levels in high dosage GH injected rats were significantly elevated in comparison to control rats, but those in low dosage GH injected rats did not
The significant result of this experiment is that the insulin sensitivity and triglyceride content of skeletal muscle in rats would be insignificantly affected by low dosage of GH injection

Summary

Introduction

The over the past decades, GH administration has been accepted as anti–ageing, physical growth, and bone health treatments in medical clinics, and the physiological effects of GH are well presented in the literature (Doga et al 2006; Henwood et al 2002; Woodhouse et al 2006). It has been widely accepted that increased plasma FFA concentrations could accelerate the increase in intramuscular triglyceride content, which might contribute to deterioration of insulin sensitivity in skeletal muscle of rats (Jung et al 2010). According to previous our results, GH injection (130 mg/kg/6 days/4 weeks) in rats caused the increase in insulin resistance and triglyceride contents in skeletal muscle (Park et al 2008). These results could be suggested that GH treatment might develop the skeletal insulin resistance even though other beneficial therapeutic effects of GH treatment have been believed in clinic. We examined the effects of high- and low- dosage of GH treatment and hypothesized that it will be different in elevated muscle triglyceride level and deteriorate insulin sensitivity

Methods

Results

Conclusion