Comparison of intraoperative subtraction pachymetry and postoperative anterior segment optical coherence tomography of laser in situ keratomileusis flaps

Abstract

To prospectively compare intraoperative subtraction pachymetry flap thickness measurements and postoperative anterior segment optical coherence tomography (AS-OCT) flap thickness measurements in eyes that had laser in situ keratomileusis (LASIK) flap creation with a femtosecond laser or a mechanical microkeratome. Stanford Eye Laser Center, Stanford University School of Medicine, Stanford, California, USA. Comparative case series. Each patient received wavefront-guided LASIK using an Intralase femtosecond laser in 1 eye and a Hansatome mechanical microkeratome in the fellow eye. Flap morphology was assessed with an ultrasound pachymeter intraoperatively and an AS-OCT system postoperatively at 1 year. Thirty-six eyes (18 patients) were enrolled. Intraoperative subtraction pachymetry consistently underestimated mechanical microkeratome flap thickness compared with postoperative AS-OCT (P<.001). There was no significant difference between intraoperative subtraction pachymetry and postoperative AS-OCT measurements for femtosecond flaps (P=.38). The overall mean variation in flap thickness (ie, mean deviation from targeted flap thickness) was 2.6μm (range 3 to 11 μm) with the femtosecond laser and 14.2 μm (range 17 to 52 μm) with the mechanical microkeratome (P<.001). Postoperative AS-OCT measurements showed femtosecond flaps had a planar configuration and mechanical microkeratome flaps had a meniscus-shaped configuration. The femtosecond laser created more uniformly planar flaps than the mechanical microkeratome as measured by intraoperative subtraction pachymetry and postoperative AS-OCT. Postoperative AS-OCT measurements varied less than intraoperative subtraction pachymetry measurements for mechanical microkeratome flaps. Neither author has a financial or proprietary interest in any material or method mentioned.