Comparison of I.V. Glycopyrrolate and Atropine in the Prevention of Bradycardia and Arrhythmias Following Repeated Doses of Suxamethonium in Children

Abstract

The effectiveness of administration of grycopyrrolate 5 and 10 μg kg−1 and atropine 10 and 20 μg kg−1 i.v. immediately before the induction of anaesthesia, to prevent arrhythmia and bradycardia following repeated doses of suxamethonium in children, was studied. A control group was included for comparison with the lower dose range of grycopyrrolate and atropine. A frequency of bradycardia of 50% was noted in the control group, but this was not significantly different from the frequency with the active drugs. Bradycardia (defined as a decrease in heart rate to less than 50 beat min−1) was prevented when the larger dose of either active drug was used. It is recommended that either glycopyrrolate 10 mg kg−1 or atropine 20 μg kg−1 i.v. should immediately precede induction of anaesthesia, in children, if the repeated administration of suzamethonium is anticipated