Comparison of Human Menopousal Gonadotropin with Recombinant Follicle Stimulating Hormone in Ovulation Stimulation During Intrauterine Insemination

Abstract

Fecundability increases when ovulation induction was conducted before starting intrauterine insemination procedure (IUI). Human Menopousal gonadotrophin (HMG) and recombinant follicle stimulating hormone (rFSH) are gonadotropin hormones that are widely used in the stimulation of ovulation in infertile patients. Although comparison of gonadotropin preparations have been carried out in IVF, but comparison of rFSH preparations and HMG on IUI was still lacking. The aim of this study was to compare rFSH and HMG, each was combined with clomiphene citrate in infertile women undergone intrauterine insemination (IUI). This study was a retrospective study in the Department of Obstetrics and Gynecology Wahidin Sudirohusodo. Samples were infertile patients who meet these following criteria: women aged 20-45 years, infertility of unknown cause for approximately 12 months, had a history of induced ovulation for approximately 6 cycles without IUI, IVF or ICSI, patent tubes examined with hysterosalpingography, and normal semen analysis according to 1999 WHO criteria. A total of 78 patients consisted of 30 patients using clomiphene citrate + rFSH and 48 other patients using clomiphene citrate + HMG. In two groups, total dosage, duration of gonadotropin administration, follicle count, mean size of follicles, endometrial line size and pregnancy were compared. Statistical test using Levene T and unpaired t test was conducted using SPSS 16 for Windows version. There was no statistically significant difference among total dosage, duration of gonadotropins administration, follicle counts, mean size of follicles, and endometrial line size. The mean number of pregnancy was higher in patients treated with clomiphene citrate + hMG but this difference was not statistically significant. hMG and rFSH was equally effective in stimulating ovulation in intrauterine insemination.